Cobalt ions influence proliferation and function of human osteoblast-like cells

Effect of particulate cobalt, chromium and cobalt-chromium alloy on human osteoblast-like cells in vitro.

Survival, proliferation, and migration of human meningioma stem-like cells in a nanopeptide scaffold

Objective(s): In order to grow cells in a three-dimensional (3D) microenvironment, self-assembling peptides, such as PuraMatrix, have emerged with potential to mimic the extracellular matrix. The aim of the present study was to investigate the influence of the self-assembling peptide on the morphology, survival, proliferation rate, migration potential, and differentiation of human meningioma st...

The effects of particulate cobalt, chromium and cobalt-chromium alloy on human osteoblast-like cells in vitro.

Particulate wear debris can induce the release of bone-resorbing cytokines from cultured macrophages and fibroblasts in vitro, and these mediators are believed to be the cause of the periprosthetic bone resorption which leads to aseptic loosening in vivo. Much less is known about the effects of particulate debris on the growth and metabolism of osteoblastic cells. We exposed two human osteoblas...

Orexin B inhibits proliferation and stimulates specialized function of cultured rat calvarial osteoblast-like cells.

Orexin-A (OXA) and orexin-B (OXB) are polypeptides derived from the same 130 amino acid long precursor (prepro-orexin) that bind and activate two closely related orphan G protein-coupled receptors OX1-R and OX2-R. These hypothalamic neuropeptides stimulate food intake and energy expenditure and play a significant role in sleep-wakefulness regulation. Present studies aimed to investigate the eff...

Variation of pH in lysed platelet concentrates influence proliferation and alkaline phosphatase activity in human osteoblast-like cells.

Activated platelets release a multifaceted blend of growth factors that has stimulatory effects on mesenchymal cells, both in vitro and in vivo, which imply beneficial effects on wound repair and tissue regeneration. Previous studies on fibroblast cultures have revealed that more potent growth factors, with respect to cell proliferation, are released in acidic preparations of lysed platelet con...